The same five steps I run in my head every time someone calls — now written down so you can follow them too.

People ask me this all the time. They’ll describe a cough, or a pain in their side, or a headache that won’t quit, and then they’ll say: “Jim, how do you just know which formula to reach for?” For years my honest answer was — I don’t know how I know. I’ve been using Dr. James’ formulas since 1980, and after that long the steps run so fast I stopped being able to see them.
So I sat down and slowed it all the way down. And it turns out there is a method — the same one Dr. Michael E. James taught and the one I’ve been running on instinct for forty years. It’s five steps. Once you see them, you can do this too. That’s the whole point of writing it down.
Here’s the picture first, then I’ll walk you through it the way I’d walk a customer through a phone call.
Why “what’s good for a headache?” is the wrong question
Most folks come at this backwards. They’ve got a symptom, and they want a product that’s stamped with that symptom — a headache pill for a headache, a cough pill for a cough. That’s how the drugstore aisle is built, so it’s how we’ve all been trained to think.
But Dr. James taught me something different, and it’s held up for forty years: a symptom is a signal, not the problem itself. The headache is the smoke. My job isn’t to chase the smoke around the room — it’s to find the fire. Find the system or the organ that’s asking for help, feed it, and let the body do its own healing. That’s the whole philosophy behind every one of these formulas.
Which means the first thing I do on a call is almost never name a product. I start asking questions. And those questions follow a path.
The five steps, the way I actually run them
Step 1 — Locate it
I want to know where the trouble is, and I’ll keep narrowing until the answer points me at a formula. Sometimes that’s a whole body system. If somebody’s dealing with a pinched nerve, or spinal trouble, or nerve pain anywhere — I don’t need to know the exact spot. The whole nervous system points me to Nerquilizer, and that’s enough.
Other times I have to dig further. Somebody says “my stomach hurts” and that’s not enough to go on. Left side or right? Up under the ribs? When they tell me it’s the right side, just below the ribs, now the location itself has done the work — that’s liver or gallbladder. I stop narrowing the moment the answer matches a formula.
Step 2 — Read the condition
Now I name what’s really going on in that spot. “Cough” isn’t enough — is there mucus to move, or is it a lung that got worn down by a cold? “Pain” isn’t enough — is it a spasm, an infection, an inflammation? This is the step that tells me what job the formula has to do.
Step 3 — Count the jobs
Then I ask how many things need doing. There are only three answers:
- Acute only. One formula to settle the thing that’s bothering them right now.
- Restore only. One formula to rebuild. A broken bone is just Tissue Mend — there’s nothing acute to chase, you’re only rebuilding.
- Both. Two formulas — one to relieve the problem now, one to restore the organ or tissue underneath.
And one little add-on rule: if a second part of the body got pulled into it, I add a formula for that too. A broken bone is Tissue Mend — but if the joint got involved, I add Arth Rite right alongside it.
Step 4 — Match the formula to the condition, not the anatomy
This one trips people up, so listen close. I match the formula to the condition — even if the body part is gone.
I had a woman call with that sharp right-side pain, up under the ribs. Classic gallbladder colic. She told me she’d had her gallbladder taken out years ago — first time the pain had come back since. Most people would’ve dropped it right there: no gallbladder, no gallbladder formula. But Col Cer still relieves that colic, because it answers the pattern of pain, not the organ. The formula doesn’t care whether the gallbladder is still in there.
Step 5 — The safety check (running the whole time)
This one isn’t really a last step — it runs alongside everything else. I’m always asking one quiet question in the back of my mind: could the bad version of this turn serious?
If the answer is yes, I still give them the formula — but I also tell them, plainly, to see a doctor. It’s never one or the other. The trigger isn’t the body part, it’s the stakes.
Three real ones, so you can feel the line:
Bleeding ulcer. Col Cer is right for ulcers and that whole area — so I’ll say so. But a bleeding ulcer can turn dangerous fast, so I tell them to get medical attention too. Formula plus doctor.
Spinal meningitis. Somebody wanted to help a friend’s son. Nerquilizer can support the nervous system and the swelling — but meningitis is severe, so the doctor came first and loud. Formula plus doctor.
Old gallbladder pain. That same woman told me it was mild and the first flare in years. Col Cer and Liv Clean, no doctor flag needed. The stakes just weren’t there.
The one rule for when it’s “both”
When a case needs a relieve formula and a restore formula, I start them at the same time — day one. I don’t wait for the acute thing to clear before I begin the rebuilding. The only difference is how long each one runs.
Take that gallbladder call. I started her on Col Cer for the colic and Liv Clean for the liver, both the same day. The Col Cer settles the pain and then it’s done. The Liv Clean keeps working underneath for about a month, cleaning up the thing that caused the trouble in the first place. Relieve now, restore over time — together.
Watch the whole thing run: a lingering cough
Let me put all five steps in motion on one real call, so you can see how fast it actually goes once you know the path.
A fellow calls with a cough that’s hung on since a head cold.
- Locate it. “Where’s the cough — up in your throat, or down in your lungs?” He says lungs — he can feel a little rattle, some mucus when he coughs.
- Read the condition. Two things going on: there’s material to move (the mucus), and there’s a lung that got worn down by the cold.
- Count the jobs. Both — clear it out and heal it up.
- Match the formula. Flem Up to move the mucus out of the lungs, and Monia to help the lungs heal from the cold. Start them together.
- Safety check. An ordinary cough after a cold — no red flag. (Now if he’d told me high fever and couldn’t catch his breath, that changes, and I’d point him to a doctor too.)
That’s it. Locate, read, count, match, and keep one eye on the stakes the whole time. After a while it stops feeling like five steps and starts feeling like a conversation — but the steps are still there underneath, every time.
Questions I get asked a lot
How do you pick a Dr. James formula?
I run five steps: locate where the trouble is, read what’s actually happening there, count how many jobs need doing (relieve, restore, or both), match a formula to the condition rather than the body part, and run a safety check the whole time. The location and the condition do most of the deciding for you.
Do I take one formula or two?
It depends on the jobs. If there’s only an immediate problem to settle, that’s one formula. If you’re only rebuilding — like a broken bone — that’s one too. When there’s both something to relieve and an organ to restore, that’s two, and you start them together on the same day.
What if I’ve had the organ removed — can a formula still help?
Often, yes. The formula answers the condition, not the presence of the organ. Gallbladder colic can still show up after the gallbladder’s gone, and Col Cer still relieves it. Always call us if you’re unsure for your own situation.
When should I see a doctor instead of reaching for a formula?
It’s not instead — it’s alongside. Any time a problem could turn severe or life-threatening — bleeding, anything spreading, anything that frightens you — take the supportive formula and get medical attention. When in doubt, make the call to a professional.
Not sure where your concern lands on the chart?
That’s exactly what I’m here for. Walk through it with me — I’ll help you locate it, read it, and find the formula that fits. Browse the full line at drugfreehelpstore.com, or just pick up the phone and call 888-388-4413. We’ll figure it out together.
Jim Applegate is the host of the Reality of Herbal Therapy podcast and carries forward the clinical work of Dr. Michael E. James, C.H., M.H., NMD, through Professional Herbal Instruction. He has used Dr. James’ formulas personally since 1980 and helps families find drug-free support every day at drugfreehelpstore.com · 888-388-4413.
These statements have not been evaluated by the Food and Drug Administration. Dr. James’ formulas are intended to support and nourish the body’s own systems; they are not intended to diagnose, treat, cure, or prevent any disease. Anything that may be severe, worsening, or an emergency calls for a licensed healthcare professional.


